The lead author, Dr. Arshad Jahangir, a cardiologist and professor of medicine at the Mayo Clinic in Scottsdale, Arizona, claims that “these products are not by themselves harmful.” However, a generally harmless chemical can turn harmful when combined with drugs for cardiovascular conditions.
The paper claims that several herbal treatments, including ginseng, ginkgo, garlic, black cohosh, St. John’s wort, hawthorn, saw palmetto, and echinacea, can weaken, aggravate, or worsen the negative effects of prescription heart medications, including blood thinners and cholesterol-lowering statins.
Some supplements may also raise blood pressure and heart rate, potentially complicating matters for people with cardiac conditions.
More than 25 herbal products, including 12 of the top 20 herbal supplements sold in the US, according to the American Botanical Council, are listed in the report, which was released this week and appears in the Journal of the American College of Cardiology’s February 9 issue.
What contraindicates the use of echinacea?
What foods and medicines should I stay away from while taking echinacea? Avoid anything that contains caffeine, including coffee, tea, cola, energy drinks, and other items. Echinacea can intensify the negative effects of caffeine, including headache, rapid heartbeat, and jitteriness.
Does echinacea conflict with any prescription drugs?
The purple coneflower is another name for the genus of native North American plants known as echinacea. An extract derived from the root of the herb Echinacea purpurea is the most popular herbal product in the country. Commercial echinacea preparations are often not standardized to any specific component because the plant’s active ingredient has not been discovered. The variability of the products utilized in different studies makes it challenging to evaluate the echinacea study literature. The herb is frequently used for this purpose and has been suggested as a preventative therapy for upper respiratory infections. However, it appears from the available research that taking preventive echinacea has little to no effect on the frequency, severity, or duration of upper respiratory infections. The evidence for treating upper respiratory infections seems to point to a slight favorable impact. Echinacea has not been associated with any significant herb-drug interactions, and the few and mild side effects that have been documented include nausea, dizziness, and gastrointestinal distress.
The purple coneflower is another name for the genus of plants known as echinacea, which are indigenous to the Midwest of North America. Three of the nine species of echinacea—Echinacea purpurea, Echinacea angustifolia, and Echinacea pallida—are used to make echinacea preparations. The preparation that is used the most frequently in this nation is a liquid extract prepared from E. purpurea root. There are many different trade names used to market echinacea.
Native Americans were the first to employ this plant medicinally, using E. angustifolia to cure everything from respiratory ailments to snakebites. Echinacea was employed as a blood purifier and a dizziness remedy during the 19th century. Up until the invention of current antibiotics, it was utilized as a cold and flu cure as well as an anti-infective. Echinacea is one of the top three plants sold in the US thanks to its recent revival as a remedy for upper respiratory infections (URIs). 1
What supplements ought to be avoided when using statins?
Some supplements may interfere with the effectiveness of statins if you take them to lower your blood cholesterol levels or raise your risk of side effects, some of which might be fatal. Supplements like antioxidants, red yeast rice, and grapefruit seed extract should be avoided when taking statins. Before combining statins with any dietary supplement or prescription, consult your doctor.
Echinacea and blood pressure medications: are they compatible?
There is no proof that echinacea would interact with diuretics, although several natural items, such as Siberian ginseng, St. Mary’s thistle, and grapefruit juice, have been reported to interfere with various types of blood-pressure medication.
Does echinacea make you feel more tense?
Echinacea can intensify the negative effects of caffeine, including headache, rapid heartbeat, and jitteriness.
Does echinacea thin the blood?
Darunavir (Prezista)
Rating for Interaction: Minor Use this combination with caution. Consult your healthcare practitioner.
To eliminate darunavir (Prezista), the body breaks it down. Echinacea may slow down the body’s absorption of darunavir (Prezista). Echinacea may lessen the effects of darunavir (Prezista) or raise the likelihood of negative effects when taken with it (Prezista). However, no evidence of this in people has been found.
Docetaxel (Docefrez, Taxotere)
Rating for Interaction: Minor Use this combination with caution. Consult your healthcare practitioner.
To eliminate docetaxel (Taxotere), the body breaks it down. The rate at which the body breaks down docetaxel may be impacted by echinacea (Taxotere). Echinacea may reduce the effects of docetaxel (Taxotere) or raise the risk of side effects if taken concurrently with docetaxel (Taxotere). However, no evidence of this in people has been found.
Minor Etravirine (Intelligence) Interaction Use this combination with caution. Consult your healthcare practitioner.
The body modifies and breaks down etravirine (Intelligence). Echinacea may slow down the body’s metabolism of etravirine (Intelence). Echinacea may lessen the effects of etravirine (Intelence) or enhance its negative effects when taken with it (Intelence). But humans have not yet experienced this.
Ritonavir with Lopinavir (Kaletra)
Rating for Interaction: Minor Use this combination with caution. Consult your healthcare practitioner.
The body modifies and breaks down Lopinavir/Ritonavir (Kaletra). Echinacea may slow down the body’s metabolism of lopinavir and ritonavir (Kaletra). Echinacea may either increase or decrease the effects of lopinavir/ritonavir when taken with etravirine (Intelence) (Kaletra). But humans have not yet experienced this.
Midazolam (Versed)
Rating for Interaction: Minor Use this combination with caution. Consult your healthcare practitioner.
The body modifies and degrades midazolam (Versed). It appears that echinacea slows down the body’s metabolism of midazolam (Versed). When used with echinacea, midazolam (Versed) may have more negative side effects or less positive effects (Versed). To understand the effects of echinacea on midazolam, more information is required (Versed).
Coumadin (Warfarin) Interaction Grade: Minor Use this combination with caution. Consult your healthcare practitioner.
Blood clotting is slowed down with warfarin (Coumadin). To eliminate warfarin (Coumadin), the body breaks it down. Echinacea may accelerate the breakdown of warfarin and lessen its effectiveness (Coumadin). Warfarin’s (Coumadin’s) diminished efficiency may raise the chance of clotting. Make sure to routinely get your blood tested. You might need to adjust the warfarin (Coumadin) dosage.
Dosing
FROM MOUTH:
- A 5 mL dose of Echinacea purpurea extract (Echinacin, Madaus AG, Cologne, Germany) taken twice daily for 10 days has been used to treat the common cold. It has also been used to take an extract of Echinacea purpurea called EchinaGuard (Madaus AG, Cologne, Germany), 20 drops in water every two hours on the first day that cold symptoms appear, then three times per day for up to 10 days. It has been used to administer either 5 mL eight times on the first day of cold symptoms, then three times daily for six days, or 4 mL ten times on the first day of cold symptoms of an extract of the entire Echinacea purpurea plant (Echinilin, Inovobiologic Inc., Calgary, Alberta, Canada). On the first day of cold symptoms, drink five or six times a different species of echinacea tea (Echinacea Plus, Traditional Medicinals, Sebastopol, CA), then cut back to one cup per day for the next five days.
- With an increase of 0.9 mL five times day (total dose: 4000 mg daily) at the first indication of a cold, a specialized echinacea extract (Echinaforce, A. Vogel Bioforce AG, Switzerland) has been utilized for the PREVENTION of the common cold.
Report Problems to the Food and Drug Administration
You are urged to inform the FDA of any harmful side effects from prescription medications. Contact FDA MedWatch by phone at 1-800-FDA-1088.
Which diseases are echinacea’s side effects?
What Negative Effects Are Linked to Echinacea Use?
- stomach ache.
- allergy symptoms
- modified fertility
- diarrhea.
- dizziness.
- redness (topical use)
- concomitant skin rash and fever (topical use)
- fever.
Does echinacea strengthen your defenses?
One of the most widely used herbs in America right now is echinacea. Native Americans gave the medicinal herb echinacea its name because of the prickly scales that mimic the enraged hedgehog’s spines on its enormous conical seed head (echinos is Greek for hedgehog).
Native Americans may have used echinacea for more than 400 years to treat wounds and illnesses as well as a general “cure-all,” according to archaeologists who have discovered evidence of this. Echinacea has been used historically to treat blood poisoning, diphtheria, syphilis, malaria, and scarlet fever. Although this herb was widely used in the 18th and 19th centuries, its use started to diminish in the US once antibiotics were developed. In Germany, echinacea preparations gained popularity during the course of the 20th century. In actuality, Germany has been the site of the majority of echinacea scientific research.
Today, individuals take echinacea to lessen the severity of the common cold and flu and to lessen symptoms including fever, coughing, and sore throats (pharyngitis). Echinacea is another plant that many herbalists advise taking to help the body fight infections and strengthen the immune system.
General Uses
Echinacea may include active ingredients that improve immunological function, ease pain, lessen inflammation, and have hormonal, antiviral, and antioxidant effects, according to a number of laboratory and animal studies. Because of this, qualified herbalists may suggest echinacea as a treatment for slow-healing wounds, ear infections, athlete’s foot, sinusitis, vaginal yeast (Candida) infections, ear infections, otitis media, hay fever, and slow-healing wounds. Echinacea and cichoric acid may help suppress colon cancers, according to preliminary laboratory studies. According to one study, using echinacea extract before contracting the herpes simplex virus (HSVI) may have an antiviral effect on the recurrence of cold sores.
Common Cold
It is debatable if echinacea aids in the prevention or treatment of the common cold. According to certain research, the herb can hasten your recovery. Others claim that echinacea has no effect at all on a cold. According to several clinical studies, persons who take echinacea as soon as they start to feel unwell have milder colds and experience less symptoms than those who do not. In a study of 95 patients who had fever, runny nose, scratchy throat, and other early signs of the flu and cold, it was discovered that those who drank many cups of echinacea tea daily for five days felt well more quickly than those who drank tea without the herb.
Echinacea decreased cold risk by 58 percent and cold duration by 1 to 4 days, according to a study of 14 clinical trials. Some experts, however, contest these results, arguing the research had a number of flaws. Clinical trials have used a variety of echinacea formulations. It’s crucial to get a high-quality echinacea supplement and to start taking it as soon as a cold starts, numerous times each day for the first few days. For advice, consult your health care practitioner.
Is everyday use of echinacea safe?
The more frequent echinacea adverse effects are as follows:
- headaches
- dizziness
- feeling unwell
- belly pain
- constipation
- skin repercussions (redness, itchiness and swelling)
- Children are more likely to have them.
Echinacea use for longer than 8 weeks at a time may cause liver damage or immune system suppression. If you are taking medications known to have an adverse effect on your liver, herbalists advise against taking echinacea.
If you use any additional medications, herbs, or supplements, check with your doctor first.
Using echinacea safely
If you want to substitute echinacea for your cancer therapy, let your doctor know. Additionally, if you are considering taking it concurrently with your cancer therapy.
In some people, it may not be safe to use in conjunction with other cancer treatments.
Echinacea may impair the effectiveness of some chemotherapy medications, including etoposide.
Sometimes pharmacists and medical professionals advise lymphoma patients not to consume echinacea. This is so that it won’t affect how they’re being treated.
Researchers discovered that echinacea and etravine were safe to ingest together in HIV-positive individuals.
If any of the following apply to you before consuming echinacea:
- are breastfeeding or pregnant
- have a medical condition like autoimmune illness, HIV, or AIDS that impairs your immune system
- are medicating to weaken your immune system because it might fight them
- are under 12 years old
- There is a possibility of allergic responses including skin rashes, according to the medical health regulatory association (MHRA).
Always discuss the use of complementary or alternative cancer therapy with your doctors and nurses. They could affect how well your other therapies work.
Your treatment team can point you in the direction of further resources if they don’t have the knowledge you need.
Do vitamins interact with statins?
Statin medications and multivitamins There are no known interactions between multivitamin and mineral supplements and statin medicines. As a reminder, it’s crucial to discuss which supplements are best for you with your doctor.
Does vitamin D interact with statins?
The risk of cardiovascular illnesses is decreased by a known class of medications called statins that lower cholesterol levels (CVDs). Myalgia is one of the worst side effects of statins, though. It’s interesting to note that muscle soreness brought on by a vitamin D deficiency has also been associated with statin interactions. Reviewing the mechanism of interaction between vitamin D and statins is justified in light of the numerous conflicting studies about the impact of vitamin D levels on statin function and myalgia.
Inactivity and increased toxicity of CYP metabolized statins may be caused in some patients by insufficient CYP enzyme activity associated to vitamin D insufficiency. Based on the previously described mechanisms, we propose that prescribing vitamin D together with atorvastatin may result in a reduction in the medication’s dosage requirements. The risk of side effects, such as myopathy, from atorvastatin, simvastatin, fluvastatin, and lovastatin may be reduced by vitamin D as well. The impact of a vitamin D supplement on the dosage requirements or adverse effects of pravastatin, rosuvastatin, and pitavastatin may be minimal or nonexistent. Due to its slight HMG-CoA reductase action, vitamin D will complement all statins. According to recent research on the role of vitamin D in CADs, vitamin D supplementation will also offer further protection against stroke33, as well as financial advantages from decreased drug costs.
Although we have attempted to address one facet of the interaction between statins and vitamin D in this article—namely, the impact of vitamin D levels on the efficacy and toxicity of statins—the overall picture of this interaction is, at best, nebulous. Statins have varied impacts on vitamin D levels in people, according to several research. 3437 It has been suggested that the reported positive effects of rosuvastatin in the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) were partially related to a statin-induced elevation of vitamin D blood levels in a vitamin D-deficient population. For instance, rosuvastatin robustly increases vitamin D levels38. 39 In conclusion, more research is needed to clarify the mechanism causing statin-induced increases in vitamin D levels.
To establish a causal relationship between vitamin D and statins, it is crucial that studies be conducted using each unique statin, as well as matched blinded controls and placebo controls. Extrapolating from this research and using its results as a stepping stone towards more complex statin-vitamin D interactions may be sensible.