In general, echinacea is safe to consume, and serious adverse effects seem to be uncommon.
The more frequent echinacea adverse effects are as follows:
- headaches
- dizziness
- feeling unwell
- belly pain
- constipation
- skin repercussions (redness, itchiness and swelling)
- Children are more likely to have them.
Echinacea use for longer than 8 weeks at a time may cause liver damage or immune system suppression. If you are taking medications known to have an adverse effect on your liver, herbalists advise against taking echinacea.
If you use any additional medications, herbs, or supplements, check with your doctor first.
Using echinacea safely
If you want to substitute echinacea for your cancer therapy, let your doctor know. Additionally, if you are considering taking it concurrently with your cancer therapy.
In some people, it may not be safe to use in conjunction with other cancer treatments.
Echinacea may impair the effectiveness of some chemotherapy medications, including etoposide.
Sometimes pharmacists and medical professionals advise lymphoma patients not to consume echinacea. This is so that it won’t affect how they’re being treated.
Researchers discovered that echinacea and etravine were safe to ingest together in HIV-positive individuals.
If any of the following apply to you before consuming echinacea:
- are breastfeeding or pregnant
- have a medical condition like autoimmune illness, HIV, or AIDS that impairs your immune system
- are medicating to weaken your immune system because it might fight them
- are under 12 years old
- There is a possibility of allergic responses including skin rashes, according to the medical health regulatory association (MHRA).
Always discuss the use of complementary or alternative cancer therapy with your doctors and nurses. They could affect how well your other therapies work.
Your treatment team can point you in the direction of further resources if they don’t have the knowledge you need.
What negative effects might echinacea overuse cause?
Echinacea is probably short-term safe for the majority of people when taken orally. It is safe to utilise different echinacea products for up to 10 days. Some products, like Echinaforce (A. Vogel Bioforce AG), offer a six-month safe usage period.
The most frequent adverse reactions are rash, diarrhoea, heartburn, constipation, and stomach pain. Some people may experience adverse responses, particularly those who are allergic to ragweed, mums, marigolds, or daisies.
Echinacea may be safe for short-term use when applied topically. Echinacea-containing cream (Linola Plus Cream) has been used safely for up to 12 weeks. Echinacea topical application may result in skin redness, itching, or rashes.
If you take echinacea, is there anything you shouldn’t take?
What foods and medicines should I stay away from while taking echinacea? Avoid anything that contains caffeine, including coffee, tea, cola, energy drinks, and other items. Echinacea can intensify the negative effects of caffeine, including headache, rapid heartbeat, and jitteriness.
Introduction
Popular herbal remedy echinacea is made from the flowering plant echinacea purpurea, which is indigenous to the eastern United States east of the Rocky Mountains. Echinacea has traditionally been used to treat and prevent upper respiratory conditions like the common cold. The use of echinacea has been linked to isolated cases of elevated serum enzyme levels and clinically obvious liver damage, despite the fact that it is typically well tolerated with few and moderate side effects.
Background
Echinacea (ek” I nay’ sha), also known as American coneflower and a perennial plant native to North America, is the source of this widely used herb. To manufacture teas, juices, extracts, capsules, or tablets, the echinacea plant’s aerial portions and roots are employed, either fresh or dried. The primary use is for the treatment or prevention of upper respiratory infections, but it is also said to have other uses, including the improvement of immune function, protection against other viral, bacterial, and fungal infections, and the relief of anxiety, migraine headaches, dyspepsia, skin rashes, and bee stings. There are at least 9 different species of echinacea, and their medicinal properties can vary. The most widely used extracts come from Echinacea purpurea, pallida, and angustifolia, which are used in thousands of commercial herbal and nutritional products. Although the exact composition of the active components in echinacea is unknown, plant extracts do contain a variety of polysaccharides, volatile oils, caffeic and ferulic acid derivatives, flavonoids, alkamides, and polyenes. Mixed findings have been found in controlled studies of echinacea in the prevention and treatment of common upper respiratory infections, and the majority of systematic reviews have come to the conclusion that there is little proof of its therapeutic efficacy. Echinacea extracts, however, have consistently been reported to be well tolerated and free of serious side effects. Minor stomach discomfort and skin rashes have been the most often reported side effects. Rare allergic responses have been reported, including urticaria, angioedema, and anaphylaxis.
Hepatotoxicity
Echinacea by itself has not been connected to liver injury in several controlled trials, either in the form of temporary serum enzyme increases or clinically obvious acute liver impairment. Toxic hepatitis and high serum aminotransferase levels have been linked to echinacea, according to summary data from national registries of adverse reactions. However, there have been sporadic case reports of clinically evident liver impairment with jaundice. There were little data about the liver damage, but according to two published accounts, hepatitis with jaundice appeared one to three weeks after commencing echinacea extracts, with moderate jaundice, noticeable ALT and AST rises, and a swift and complete recovery upon discontinuing. One of the cases had autoimmune characteristics, but neither instance displayed hypersensitive characteristics (fever, rash, lymphadenopathy or eosinophilia). It is unknown whether the cases were caused by a specific species, a method of preparation, or product contamination because of the variety in the components of echinacea products.
What advantages come from taking echinacea regularly?
Echinacea may boost your immune system, enabling you to combat viral or bacterial colds and flu. According to certain studies, the echinacea plant includes compounds that aid in the production of white blood cells by your body. These white blood cells function as part of your immune system to combat infection when your upper respiratory tract (nose, mouth, and throat) becomes infected.
But a 2014 research that examined two dozen additional studies discovered only flimsy proof that echinacea supplements actually work to treat colds. Echinacea may help treat colds, but it has not been demonstrated to hasten the onset of a cold.
Several different infections may be repelled by echinacea. According to some research, echinacea helps treat ear infections, urinary tract infections, and slow-healing cuts and wounds. Even though echinacea can occasionally assist with small illnesses, if the issue persists, you should visit a doctor.
Can echinacea be taken with vitamin D?
Vitamin D3 and echinacea did not interact in any way. This does not imply that there are no interactions, though. Always get advice from your doctor.
Brief overview
However, no studies utilising Echinacea in the prevention or treatment of illnesses similar to COVID-19 have been found. Current research suggests that echinacea supplementation may reduce the duration and severity of acute respiratory tract infections. There were not many side events reported, indicating the relative safety of this herbal medication. Clinical studies have shown that Echinacea lowers levels of immunological molecules associated with cytokine storm, despite the fact that it might boost immune activity, which raises concerns that it can worsen over-activation of the immune system in cytokine storm.
Verdict
When given at the earliest sign of infection, Echinacea supplements may help with the symptoms of acute respiratory infections (ARI) and the common cold. No trials employing Echinacea in the prevention or treatment of illnesses like COVID-19, however, have been found. When taken at the outset of symptoms, Echinacea may lessen the intensity and/or duration of ARI, according to earlier research. E. purpurea or a mixture of E. purpurea and E. angustifolia having standardised levels of active components were employed in trials claiming benefit.
Echinacea use hasn’t been associated with many side effects, which suggests that this herbal remedy is generally harmless. No human studies using echinacea for up to 4 months could be found that showed cytokine storm symptoms.
The results were largely consistent with a reduction in the pro-inflammatory cytokines that are involved in the progression of cytokine storm and Acute Respiratory Distress Syndrome (ARDS), factors that are highly significant in the death of COVID-19 patients when looking at all human trials that reported changes in cytokine levels in response to Echinacea supplementation. Even though there isn’t any research on the therapeutic benefits of echinacea in the treatment of cytokine storms right now, this evidence shows that more study is necessary.
Echinacea and kidney health
If you have renal illness, stay away from herbal medications because they can increase blood pressure.
Some, like St. John’s Wort (for poor mood), may interfere with renal disease medications.
Before using some, such as the cold and flu treatment echinacea, consult with your doctor or pharmacist because they may have an adverse effect on kidney function.
Another issue is that the amount of the active ingredient in herbal remedies can vary significantly across brands (and even between batches of the same brand). This makes it challenging to anticipate how potent a dose will be.
Positive effect on the immune System
Numerous studies have revealed that this plant may support your immune system’s ability to fight viruses and infections, which may speed up your recovery from illness (8, 9, 10).
Echinacea is frequently used to either prevent or treat the common cold because of this.
In fact, a review of 14 studies revealed that echinacea supplementation may reduce the likelihood of getting a cold by more than 50% and shorten its duration by 1.5 days (11).
Numerous research on the subject, nevertheless, have a weak design and offer little genuine value. Due to this, it can be difficult to determine if echinacea use has any beneficial effects on colds vs random events (12).
In conclusion, echinacea may increase immunity, but it is unknown how it may affect the common cold.
May lower blood sugar levels
This includes heart disease, type 2 diabetes, and a number of other chronic illnesses.
Research in test tubes suggests that echinacea plants may aid in lowering blood sugar levels.
An Echinacea purpurea extract was demonstrated in a test-tube investigation to inhibit enzymes that break down carbs. If you ate this, it would lower the quantity of sugar that entered your blood (13).
By activating the PPAR-y receptor, a popular target of diabetic medications, echinacea extracts were found to increase cells’ sensitivity to the effects of insulin in additional test-tube tests (14, 15).
A risk factor for insulin resistance, excess blood fat is eliminated by this specific receptor. As a result, cells respond to insulin and sugar more quickly (16).
Research on how echinacea affects blood sugar in humans is still inadequate.
May reduce feelings of anxiety
Nearly one in five American adults suffer from anxiety, which is a widespread problem (17).
According to research, echinacea plants contain substances that may help people feel less anxious. Alkamides, rosmarinic acid, and caffeic acid are a few of these (18).
Three out of five echinacea samples reduced anxiety in a mouse research. In addition, unlike higher doses of conventional treatments, they did not cause the mice to become less active (18).
Another study discovered that Echinacea angustifolia extract significantly decreased anxiety in rats and people (19).
However, there are currently very few studies on echinacea and anxiety. Before echinacea products are suggested as a potential treatment, more research is required.
Anti-inflammatory properties
Your body naturally promotes healing and defends itself by inducing inflammation.
Inflammation can occasionally become out of control and persist longer than intended and necessary. This could increase your risk of developing chronic illnesses and other health issues.
Echinacea chemicals reduced significant inflammatory markers and inflammation-related memory loss in a mouse research (20).
Adults with osteoarthritis who took a supplement containing echinacea extract for 30 days noticed a significant decrease in swelling, chronic pain, and inflammation.
Interestingly, echinacea extract-containing supplements were effective for these adults even though they did not respond well to traditional non-steroidal anti-inflammatory medicines (NSAIDS) (21).
May help treat skin concerns
In a test-tube experiment, researchers discovered that the anti-inflammatory and antibacterial characteristics of echinacea inhibited the growth of Propionibacterium, a common acne-causing bacteria (22).
Another study on 10 healthy adults aged 25 to 40 found that using skin care products with echinacea extract increased skin moisture and decreased wrinkles (23).
Similar to this, it has been demonstrated that a cream containing Echinacea purpurea extract can lessen eczema symptoms and aid in repairing the skin’s thin, protective outer layer (24).
Echinacea extract doesn’t seem to have a long shelf life, making it challenging to use in industrial skin care products.